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Wirkteppich von Edward Burne-Jones

Ligand diffusion enables force-independent cell adhesion via activating α5β1 integrin and initiating Rac and RhoA signaling Leixiao Yu, Yong Hou, Wenyan Xie, Jose Luis Cuellar Camacho, Chong Cheng, Andrew Holle, Jennifer Young, Britta Trappmann, Weifeng Zhao, Matthias F. Melzig, Elisabetta A. Cavalcanti‐Adam, Changsheng Zhao, Joachim P. Spatz, Qiang Wei, and Rainer Haag

Erscheinungsform:	Aufsatz
Autor/Urheber:	Yu, Leixiao
Beteiligte:	Hou, Yong Xie, Wenyan Camacho, Jose Luis Cuellar Cheng, Chong Holle, Andrew W. Young, Jennifer Trappmann, Britta Zhao, Weifeng Melzig, Matthias F. Cavalcanti-Adam, Elisabetta A. Zhao, Changsheng Spatz, Joachim P. Wei, Qiang Haag, Rainer
Umfang:	12
Nebentitel:	Ligand diffusion enables force-independent cell adhesion via activating alpha 5 beta 1 integrin and initiating Rac and RhoA signaling
Anmerkungen:	Gesehen am 21.10.2020
Identifikatoren/Sonstige Nummern:	173608237X [PPN]
In:	Weinheim : Wiley-VCH, 1989 32(2020,29) Artikel-Nummer 2002566, 12 Seiten volume:32 year:2020 number:29 pages:2002566 extent:12
Inhalt:	Cells reside in a dynamic microenvironment in which adhesive ligand availability, density, and diffusivity are key factors regulating cellular behavior. Here, the cellular response to integrin-binding ligand dynamics by directly controlling ligand diffusivity via tunable ligand-surface interactions is investigated. Interestingly, cell spread on the surfaces with fast ligand diffusion is independent of myosin-based force generation. Fast ligand diffusion enhances α5β1 but not αvβ3 integrin activation and initiates Rac and RhoA but not ROCK signaling, resulting in lamellipodium-based fast cell spreading. Meanwhile, on surfaces with immobile ligands, αvβ3 and α5β1 integrins synergistically initiate intracellular-force-based canonical mechanotransduction pathways to enhance cell adhesion and osteogenic differentiation of stem cells. These results indicate the presence of heretofore-unrecognized pathways, distinct from canonical actomyosin-driven mechanisms, that are capable of promoting cell adhesion.
URL:	https://doi.org/10.1002/adma.202002566
Weiter im Partnersystem:	https://swb.bsz-bw.de/DB=2.1/PPNSET?PPN=173608237X

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